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Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine.

Annual review of pathology - 24 Jan 2022

Dermawan Josephine K, Rubin Brian P

Abstract excerpt

Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primary activating driver mutations (focusing on KIT and PDGFRA), oncogene addiction and targeted therapies with imatinib and other tyrosine kinase inhibitors, and the subsequent...

Topics

Antineoplastic Agents
Drug Resistance, Neoplasm
Gastrointestinal Stromal Tumors
Humans
Mutation
Precision Medicine
Proto-Oncogene Proteins c-kit
Receptor, Platelet-Derived Growth Factor alpha

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34736340
DOI: 10.1146/annurev-pathol-042220-021510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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