Article
Gastrointestinal stromal tumors.
Current topics in microbiology and immunology - 1 Jan 2012
Antonescu Cristina
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract. Nearly all tumors have a mutation in the KIT or, less often, platelet-derived growth factor receptor (PDGFRA) or B-rapidly Accelerated Fibrosarcoma (BRAF) gene. The discovery of constitutive KIT activation as the central mechanism of GIST pathogenesis, suggested that inhibiting or blocking KIT signaling might be the...
Topics
- Antineoplastic Agents
- Benzamides
- Cell Proliferation
- Drug Resistance, Neoplasm
- Enzyme Activation
- Exons
- Gastrointestinal Stromal Tumors
- Humans
- Imatinib Mesylate
- Indoles
- Liver Neoplasms
- Molecular Targeted Therapy