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Article

Gastrointestinal stromal tumors (GISTs): from science to targeted therapy.

The International journal of biological markers - 1 Jan 2000

Sarmiento R, Bonginelli P, Cacciamani F, Salerno F, Gasparini G

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs represent a distinct category of tumors characterized by oncogenic mutations of the KIT receptor tyrosine kinase in a majority of patients. KIT is useful not only for the diagnosis but also for targeted therapy of this disease. Imatinib, a tyrosine kinase inhibitor, is widely used in advanced and...

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PMID: 18629782
DOI: 10.1177/172460080802300206

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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