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Article

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2008

Tai S J, Herzog R W, Margaritis P, Arruda V R, Chu K, Golden J A, Labosky P A, High K A

Abstract excerpt

BACKGROUND: Activated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans with complete deficiency of FX, and knockout of murine F10 is embryonic or perinatal lethal. OBJECTIVE: We sought to generate a viable mouse model of FX deficiency. METHODS: We used a socket-targeting construct to...

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Identifiers

PMID: 18036190
DOI: 10.1111/j.1538-7836.2008.02849.x
PMCID: PMC2471867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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