Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA hypomethylation is crucial for apoptotic DNA to induce systemic lupus erythematosus-like autoimmune disease in SLE-non-susceptible mice

5 Aug 2007

Abstract excerpt

OBJECTIVES: Systemic lupus erythematosus (SLE) is characterized by serological presence of anti-double-stranded DNA (dsDNA) antibodies and its pathogenesis remains unclarified. Our previous work found that syngeneic activated lymphocyte-derived DNA (ALD-DNA) induced SLE-like autoimmune disease in the SLE-non-prone BALB/c mice. Here, the biological and chemical characteristics of the somatic DNA were focused upon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Parvovirus B19 Infection Studies
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18032537
DOI: 10.1093/rheumatology/kem275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA hypomethylation is crucial for apoptotic DNA to induce systemic lupus erythematosus-like autoimmune disease in SLE-non-susceptible micePMID 18032537Read ↗

Pathogenesis and potential therapeutic targets in systemic lupus erythematosus: from bench to bedsideSemantic proximity Read ↗

Selective Memory to Apoptotic Cell–Derived Self-Antigens with Implications for Systemic Lupus Erythematosus DevelopmentSemantic proximity Read ↗

Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and EffectsSemantic proximity Read ↗

Systemic Lupus Erythematosus and DNA Degradation and Elimination DefectsSemantic proximity Read ↗

Abnormal DNA methylation and deoxycytosine‐deoxyguanine content in nucleosomes from lymphocytes undergoing apoptosisSemantic proximity Read ↗

DNA Damage and Deficiencies in the Mechanisms of Its Repair: Implications in the Pathogenesis of Systemic Lupus ErythematosusSemantic proximity Read ↗

The Role of Extracellular DNA in Autoimmunity in SLESemantic proximity Read ↗

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus.Semantic proximity Read ↗

DNA-dependent Activator of Interferon-regulatory Factors (DAI) Promotes Lupus Nephritis by Activating the Calcium PathwaySemantic proximity Read ↗

DNA Damage Response and Oxidative Stress in Systemic AutoimmunitySemantic proximity Read ↗

The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could BeSemantic proximity Read ↗

Triggers for anti-chromatin autoantibody production in SLESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.