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Article

DNA Damage Response and Oxidative Stress in Systemic Autoimmunity

20 Dec 2019

Abstract excerpt

The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular defense. On the other hand, a deregulated interplay between these systems underlines inflammatory diseases including malignancies and chronic systemic autoimmune...

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PMID: 31861764
DOI: 10.3390/ijms21010055

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