Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus.

Rheumatology (Oxford, England) - 1 Feb 2003

Yasutomo K

Abstract excerpt

Systemic lupus erythematosus (SLE) is one of the autoimmune diseases extensively studied by immunologists and physicians. The main focus regarding SLE pathophysiology has been placed on abnormal cell surface receptor function on lymphocytes. However, recent studies have revealed that defective clearance of apoptotic cells causes self-antigen accumulation, which could trigger the activation of autoreactive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Autoimmunity
Share to Deoxyribonuclease I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Lupus Erythematosus, Systemic

Share to Lymphocyte Activation

Share to Mutation

Share to T-Lymphocytes

Source

Identifiers

PMID: 12595613
DOI: 10.1093/rheumatology/keg081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus.PMID 12595613Read ↗

DNaseI in pathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

Pathogenesis and potential therapeutic targets in systemic lupus erythematosus: from bench to bedsideSemantic proximity Read ↗

New insights into the immunopathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

Immunopathogenesis of systemic lupus erythematosus: An update.Semantic proximity Read ↗

Mendelian Causes of Autoimmunity: the Lupus Phenotype.Semantic proximity Read ↗

The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic RegulationSemantic proximity Read ↗

Recent insights into the genetic basis of systemic lupus erythematosus.Semantic proximity Read ↗

Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and EffectsSemantic proximity Read ↗

Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus.Semantic proximity Read ↗

The role of dendritic cells in the pathogenesis of systemic lupus erythematosusSemantic proximity Read ↗

Systemic Lupus Erythematosus and DNA Degradation and Elimination DefectsSemantic proximity Read ↗

Triggers for anti-chromatin autoantibody production in SLESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.