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Article

Selective Memory to Apoptotic Cell–Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development

25 Aug 2016

Abstract excerpt

Autoimmune diseases are characterized by pathogenic immune responses to self-antigens. In systemic lupus erythematosus (SLE), many self-antigens are found in apoptotic cells (ACs), and defects in removal of ACs from the body are linked to a risk for developing SLE. This includes pathological memory that gives rise to disease flares. In this study, we investigated how memory to AC-derived self-antigens develops...

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Identifiers

PMID: 27559051
DOI: 10.4049/jimmunol.1401129

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