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Article

High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.

Breast cancer research and treatment - 1 Oct 2008

van der Groep Petra, Bouter Alwin, Menko Fred H, van der Wall Elsken, van Diest Paul J

Abstract excerpt

Hypoxia is a hallmark of cancer. Hypoxia inducible factor-1alpha (HIF-1alpha) is the key regulator of the hypoxia response. HIF-1alpha is overexpressed during sporadic breast carcinogenesis and correlated with poor prognosis. Little is known on the role of HIF-1alpha in hereditary breast carcinogenesis. A recent study suggests a role for BRCA1 in HIF-1alpha regulation. We therefore examined the expression of...

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Share to BRCA1 Protein
Share to Cell Hypoxia
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Identifiers

PMID: 18030615
DOI: 10.1007/s10549-007-9817-z

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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