Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-induced factor-1 alpha, vascular endothelial growth factor expression in BRCA1-related breast cancer: A prospective study in tertiary care hospital.

Indian journal of pathology & microbiology - 1 Jan 2000

Sharma Manisha, Piplani Sanjay, Madan Manas, Manjari Mridu, Garg Saumil, Kaur Komalpreet

Abstract excerpt

INTRODUCTION: Breast cancer is the commonest cause of death among middle aged women. BRCA1 associated tumors carry a poor prognosis. Angiogenesis is considered necessary for tumor growth and for its metastasis. Hypoxia stimulates HIF-1α which then activates transcription of various proangiogenic cytokines like VEGF. In the present study we examined HIF-1α expression, sVEGF levels and BRCA1 mutations and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocytochemistry

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Immunohistochemistry

Share to Microscopy

Share to Tertiary Care Centers

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 29323057
DOI: 10.4103/IJPM.IJPM_524_16

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-induced factor-1 alpha, vascular endothelial growth factor expression in BRCA1-related breast cancer: A prospective study in tertiary care hospital.PMID 29323057Read ↗

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.Semantic proximity Read ↗

Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A reviewSemantic proximity Read ↗

Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients.Semantic proximity Read ↗

Hypoxia‐inducible factor 1 and cancer pathogenesisSemantic proximity Read ↗

HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancerSemantic proximity Read ↗

Hypoxia-inducible factor-1 in human breast and prostate cancerSemantic proximity Read ↗

Molecular Evaluation of HIF-1α Gene Variation and Determination of Its Frequency and Association with Breast Cancer Susceptibility in Saudi Arabia.Semantic proximity Read ↗

High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.Semantic proximity Read ↗

Strong Expression of Hypoxia-Inducible Factor-1α (HIF-1α) Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer.Semantic proximity Read ↗

Clinicopathological significance of hypoxia-inducible factor-1 alpha polymorphisms in cancers: evidence from a meta-analysis.Semantic proximity Read ↗

Association of Hypoxia-Inducible Factor 1α Gene Polymorphisms With Breast Cancer Susceptibility: A Meta-Analysis.Semantic proximity Read ↗

Immunohistochemical Evaluation of BAP1 Expression in Breast Cancer with Known BRCA1 and BRCA2 Mutations and Comparison with Histopathological Features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.