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Article

BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression.

British journal of cancer - 6 Oct 2009

Yan M, Rayoo M, Takano E A, Thorne H, Fox S B

Abstract excerpt

BACKGROUND: There are limited data regarding the hypoxia pathway in familial breast cancers. We therefore performed a study of hypoxic factors in BRCA1, BRCA2 and BRCAX breast cancers. METHODS: Immunoperoxidase staining for HIF-1alpha, PHD1, PHD2, PHD3, VEGF and FIH was carried out in 125 (38 BRCA1, 33 BRCA2 and 54 BRCAX) breast carcinomas. These were correlated with clinicopathological parameters and the...

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Share to Dioxygenases
Share to E1A-Associated p300 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to Mixed Function Oxygenases

Share to Procollagen-Proline Dioxygenase

Share to Receptors, Estrogen

Source

Open in PubMed Open full text

Identifiers

PMID: 19724277
DOI: 10.1038/sj.bjc.6605287
PMCID: PMC2768103

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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