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Article

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.

Breast cancer research and treatment - 1 Aug 2008

Yamamoto Yutaka, Ibusuki Mutsuko, Okumura Yasuhiro, Kawasoe Teru, Kai Kazuharu, Iyama Kenichi, Iwase Hirotaka

Abstract excerpt

PURPOSE: The aim of this study is to clarify characteristics of invasive breast cancer with expression of Hypoxia-induced factor 1alpha (HIF-1alpha) which is induced by hypoxia and signal transduction of growth factors. EXPERIMENTAL DESIGN: We examined, by immunohistochemical analysis, the expression of HIF-1alpha in normal breast tissue, benign disorders and breast cancer. In invasive breast cancer, we...

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Identifiers

PMID: 17805961
DOI: 10.1007/s10549-007-9742-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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