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Article

Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation.

Science translational medicine - 17 Jun 2026

Dymun Alexandria, Jeng Mark Y, Elkrief Arielle, Mehrotra Harshita, Yang Soo-Ryum, Wilson Christina, Rekhtman Natasha, Linkov Irina, Pupo Amanda, Falcon Christina, Wilhelm Clare J, Manoj Parvathy, Zhong Hong, Sridhar Harsha, Kris Mark G, Socci Nicholas D, Qiu Juan, de Stanchina Elisa, Richards Allison L, Donoghue Mark T A, Rudin Charles M, Yu Helena A, Quintanal-Villalonga Álvaro

Abstract excerpt

Histologic transformation to lung squamous cell carcinoma (LUSC) is an underrecognized mechanism of resistance in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD). Although AKT and MYC activation have been linked to LUSC features, the clinicogenomic determinants of this transformation remain undefined. In this study, we performed comprehensive clinical and multiomic profiling-including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42308331
DOI: 10.1126/scitranslmed.aea4881

Genes

EGFR
MET
MYC
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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