Article
Biology and patterns of response to EGFR-inhibition in squamous cell cancers of the lung and head & neck.
Cancer treatment reviews - 1 Mar 2017
Juergens Rosalyn A, Bratman Scott V, Tsao Ming-Sound, Laurie Scott A, Sara Kuruvilla M, Razak Albiruni R A, Hansen Aaron R
Abstract excerpt
The identification of common molecular aberrations that drive cancer progression has led to targeted therapies that improve treatment efficacy in many tumor types. Epidermal growth factor receptor (EGFR) inhibitors have been used to treat both lung and head and neck cancers with squamous cell histology. These tumors often show high EGFR expression and/or increased gene copy number, but low incidence of the...
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