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Article

A gene-alteration profile of human lung cancer cell lines.

Human mutation - 1 Aug 2009

Blanco Raquel, Iwakawa Reika, Tang Moying, Kohno Takashi, Angulo Barbara, Pio Ruben, Montuenga Luis M, Minna John D, Yokota Jun, Sanchez-Cespedes Montse

Abstract excerpt

Aberrant proteins encoded from genes altered in tumors drive cancer development and may also be therapeutic targets. Here we derived a comprehensive gene-alteration profile of lung cancer cell lines. We tested 17 genes in a panel of 88 lung cancer cell lines and found the rates of alteration to be higher than previously thought. Nearly all cells feature inactivation at TP53 and CDKN2A or RB1, whereas BRAF, MET,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19472407
DOI: 10.1002/humu.21028
PMCID: PMC2900846

Genes

ERBB2
MET
NRAS
BRAF
EGFR
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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