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Article

Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.

PloS one - 21 Nov 2007

Pavard Samuel, Metcalf C Jessica E

Abstract excerpt

The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved in women's late-onset diseases are generally considered evolutionarily neutral. Recently, genetic and...

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Identifiers

PMID: 18030340
DOI: 10.1371/journal.pone.0001206
PMCID: PMC2065908

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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