Article
Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.
Cell reports - 24 Dec 2019
Kinzina Elvira D, Podolskiy Dmitriy I, Dmitriev Sergey E, Gladyshev Vadim N
Abstract excerpt
An increase in the probability of death has been a defining feature of aging, yet human perinatal mortality starts high and decreases with age. Previous evolutionary models suggested that organismal aging begins after the onset of reproduction. However, we find that mortality and incidence of diseases associated with aging follow a U-shaped curve with the minimum before puberty, whereas quantitative biomarkers of...
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