Article
Allele age and a test for selection on rare alleles.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Nov 2000
Slatkin M
Abstract excerpt
An approximate expression for the probability distribution of the age of a neutral allele as a function of its frequency is derived for a population undergoing arbitrary changes in population size. A simple maximum-likelihood estimator of allele age based on frequency is also obtained. The distribution of allele age, combined with a model predicting the extent of intra-allelic variability generated by mutation...
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