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Article

Allele frequency trajectories across age groups reveal ongoing natural selection shaping disease susceptibility.

American journal of human genetics - 6 Aug 2026

Chen Jing-Lian, Kang Mei-Ling, Lin Cheng-Jui, Lo Yun-Hua, Chen Yann-Jang, Lee Hsiao-Hui, Tanapima Valis, Lin Chao-Kuang, Lee I-Hui, Satta Yoko, Ko Wen-Ya

Abstract excerpt

Understanding how selection shapes disease risk remains challenging. Variants influencing complex traits, including common diseases, can also impact fitness and thus be constrained by purifying selection. Consequently, genetic variance underlying disease susceptibility may be attributed to low-frequency, population-specific variants. We analyzed 509,817 genome-wide variants from 72,635 Han Taiwanese individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42497868
DOI: 10.1016/j.ajhg.2026.07.002
PMCID: PMC13504339

Genes

BRCA1
BRCA2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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