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Article

Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene.

Biochemical and biophysical research communications - 25 Jan 2008

Chen Hui, Li Zhenghua, Haruna Kyoko, Li Zhengzhe, Li Zhongzhe, Semba Kei, Araki Masatake, Yamamura Ken-Ichi, Araki Kimi

Abstract excerpt

Ribosomal DNA (rDNA) transcription by RNA polymerase I (Pol I) is an important initial step for the production of ribosomes. The RNA polymerase 1-2 (Rpo1-2) gene is comprised of 15 exons and encodes 1135 amino acids (aa) of the second largest subunit in Pol I. In a gene trap screen, we have identified an insertional mutation (Rpo1-2(Gt)) in the 14th exon of Rpo1-2, resulting in a truncation of 312aa from the...

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PMID: 18023416
DOI: 10.1016/j.bbrc.2007.11.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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