Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.

PloS one - 1 Jan 2014

Pitzonka Laura, Ullas Sumana, Chinnam Meenalakshmi, Povinelli Benjamin J, Fisher Daniel T, Golding Michelle, Appenheimer Michelle M, Nemeth Michael J, Evans Sharon, Goodrich David W

Abstract excerpt

Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute to genome instability and disease. Despite the large number of RNPs and the importance of the molecular processes they mediate, the requirements for individual RNP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunophenotyping
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Cell Lineage

Share to Granulocytes

Share to Homeostasis

Share to Myeloid Progenitor Cells

Share to Ribonucleoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24830368
DOI: 10.1371/journal.pone.0097628
PMCID: PMC4022742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.PMID 24830368Read ↗

The THO complex as a key mRNP biogenesis factor in development and cell differentiation.Semantic proximity Read ↗

An allelic series for studying the mouse Thoc1 gene.Semantic proximity Read ↗

Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.Semantic proximity Read ↗

Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiationSemantic proximity Read ↗

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.Semantic proximity Read ↗

Cryptogenic organizing pneumonia in Tomm5(-/-) mice.Semantic proximity Read ↗

Mechanisms of mRNA processing defects in inherited <i>THOC6</i> intellectual disability syndromeSemantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian developmentSemantic proximity Read ↗

<i>XPOT</i> Deficiency causes a human disorder through impaired tRNA nuclear exportSemantic proximity Read ↗

Mechanisms of mRNA processing defects in inherited THOC6 intellectual disability syndromeSemantic proximity Read ↗

Genomic Organization of the Mouse plunc Gene and Expression in the Developing Airways and ThymusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.