Article
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility.
PLoS genetics - 1 Feb 2016
de Voer Richarda M, Hahn Marc-Manuel, Weren Robbert D A, Mensenkamp Arjen R, Gilissen Christian, van Zelst-Stams Wendy A, Spruijt Liesbeth, Kets C Marleen, Zhang Junxiao, Venselaar Hanka, Vreede Lilian, Schubert Nil, Tychon Marloes, Derks Ronny, Schackert Hans K, Geurts van Kessel Ad, Hoogerbrugge Nicoline, Ligtenberg Marjolijn J L, Kuiper Roland P
Abstract excerpt
Approximately 25-30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5-10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare variants with a moderately penetrant risk. Here we aimed to identify novel risk factors for early-onset CRC using...
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