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Article

Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites.

The Journal of infectious diseases - 1 Dec 2007

Ord Rosalynn, Alexander Neal, Dunyo Sam, Hallett Rachel, Jawara Musa, Targett Geoffrey, Drakeley Christopher J, Sutherland Colin J

Abstract excerpt

BACKGROUND: Observations in natural Plasmodium falciparum populations after removal of failing drugs suggest that there is a fitness cost of drug resistance. METHODS: To examine the effect of transient removal of drug pressure, we analyzed seasonal changes in the prevalence of chloroquine (CQ)-re...

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Identifiers

PMID: 18008244
DOI: 10.1086/522154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18008244-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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