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Article

Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.

The American journal of tropical medicine and hygiene - 1 Dec 2002

Sutherland Colin J, Alloueche Ali, Curtis Jill, Drakeley Chris J, Ord Rosalynn, Duraisingh Manoj, Greenwood Brian M, Pinder Margaret, Warhurst David, Targett Geoffrey A T

Abstract excerpt

Polymorphisms in two genes of Plasmodium falciparum (P. falciparum multidrug resistance 1 [pfmdr1] and P. falciparum chloroquine [CQ] resistance transporter [pfcrt]) are associated with CQ treatment failure. We found significant linkage disequilibrium between these loci among isolates from symptomatic Gambian children (P = 0.026) and strong selection for the resistance-associated alleles pfmdr1-86Tyr and...

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Identifiers

PMID: 12518847
DOI: 10.4269/ajtmh.2002.67.578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.PMID 12518847Read ↗

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