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Article

Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia.

Malaria journal - 28 Jul 2021

Mulenga Mwenda C, Sitali Lungowe, Ciubotariu Ilinca I, Hawela Moonga B, Hamainza Busiku, Chipeta James, Mharakurwa Sungano

Abstract excerpt

BACKGROUND: In 2002, Zambia withdrew chloroquine as first-line treatment for Plasmodium falciparum malaria due to increased treatment failure and worldwide spread of chloroquine resistance. The artemisinin combination regimen, artemether-lumefantrine, replaced chloroquine (CQ) as first choice malaria treatment. The present study determined the prevalence of CQ resistance molecular markers in the Pfcrt and Pfmdr1...

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Identifiers

PMID: 34320992
DOI: 10.1186/s12936-021-03859-z
PMCID: PMC8317340

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