Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used.

PloS one - 31 Aug 2009

Ursing Johan, Kofoed Poul-Erik, Rodrigues Amabelia, Rombo Lars

Abstract excerpt

BACKGROUND: Potentially chloroquine resistant P. falciparum, identified by the 76T haplotype in the chloroquine resistance transporter (pfcrt 76T), are highly prevalent throughout Africa. In Guinea-Bissau, normal and double dose chloroquine have respective efficacies of 34% and 78% against P.falciparum with pfcrt 76T and approximately three times the normal dose of chloroquine is routinely taken. Proportions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Chloroquine
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Membrane Transport Proteins

Share to Plasmodium falciparum

Share to Protozoan Proteins

Share to Seasons

Source

Open in PubMed Open full text

Identifiers

PMID: 19718439
DOI: 10.1371/journal.pone.0006866
PMCID: PMC2729929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used.PMID 19718439Read ↗

Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?Semantic proximity Read ↗

Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.Semantic proximity Read ↗

High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana.Semantic proximity Read ↗

Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposureSemantic proximity Read ↗

Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites.Semantic proximity Read ↗

Pfcrt mutant haplotypes may not correspond with chloroquine resistance.Semantic proximity Read ↗

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicineSemantic proximity Read ↗

Chloroquine resistance transporter drives divergent multi-locus drug resistance genetic backgrounds and susceptibility in Gambian Plasmodium falciparum.Semantic proximity Read ↗

Chloroquine sensitivity: diminished prevalence of chloroquine-resistant gene marker pfcrt-76 13 years after cessation of chloroquine use in Msambweni, KenyaSemantic proximity Read ↗

Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.Semantic proximity Read ↗

Malaria transmission intensity and the rate of spread of chloroquine resistant Plasmodium falciparum: Why have theoretical models generated conflicting results?Semantic proximity Read ↗

Association of Plasmodium falciparum isolates encoding the p. Falciparum chloroquine resistance transporter gene K76T polymorphism with anemia and splenomegaly, but not with multiple infections.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.