Article
Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition.
The EMBO journal - 12 Dec 2007
Mohammad Mohammad M, Donti Taraka R, Sebastian Yakisich J, Smith Aaron G, Kapler Geoffrey M
Abstract excerpt
The Tetrahymena thermophila ribosomal DNA (rDNA) replicon contains dispersed cis-acting replication determinants, including reiterated type I elements that associate with sequence-specific, single-stranded binding factors, TIF1 through TIF4. Here, we show that TIF4, previously implicated in cell cycle-controlled DNA replication and rDNA gene amplification, is the T. thermophila origin recognition complex (TtORC)....
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