Article
Long range cooperative interactions regulate the initiation of replication in the Tetrahymena thermophila rDNA minichromosome.
Nucleic acids research - 1 Aug 1999
Reischmann K P, Zhang Z, Kapler G M
Abstract excerpt
The Tetrahymena thermophila rDNA exists as a 21 kb palindromic minichromosome with two initiation sites for replication in each half palindrome. These sites localize to the imperfect, repeated 430 bp segments that include the nucleosome-free domains 1 and 2 (D1 and D2). To determine if the D1 and D2 segments act independently or in concert to control initiation, stable DNA transformation assays were performed....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.