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Article

Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity.

Cancer research - 15 Nov 2007

Trent Sally, Yang Chuanwei, Li Cuiqi, Lynch Mary, Schmidt Emmett V

Abstract excerpt

Overexpression of cyclin D1 is associated with many cancers, and its overexpression is especially associated with a poor prognosis in breast cancer. Paradoxically, cyclin D1 is known to enhance radiation sensitivity, a finding that has not yet been therapeutically exploited. Proposed cyclin D1 functions that could be involved in this effect include cyclin-dependent kinase (CDK)-dependent phosphorylation of...

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Source

Identifiers

PMID: 18006821
DOI: 10.1158/0008-5472.CAN-07-1475

Genes

HSPB8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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