Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncovering residues that regulate cyclin D1 proteasomal degradation.

Oncogene - 2 Aug 2007

Feng Q, Sekula D, Müller R, Freemantle S J, Dmitrovsky E

Abstract excerpt

Cyclin D1 regulates G1 cell-cycle progression and is aberrantly expressed in carcinogenesis. Proteasomal degradation of cyclin D1 was highlighted as a cancer chemopreventive mechanism. To understand this mechanism better, residues responsible for degradation and ubiquitination of cyclin D1 were investigated. Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cyclin D1
Share to Cycloheximide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Proteasome Endopeptidase Complex

Share to Protein Structure, Tertiary

Share to Tretinoin

Share to Ubiquitin

Source

Identifiers

PMID: 17310991
DOI: 10.1038/sj.onc.1210309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncovering residues that regulate cyclin D1 proteasomal degradation.PMID 17310991Read ↗

Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncologySemantic proximity Read ↗

Coming of Age: Targeting Cyclin K in CancersSemantic proximity Read ↗

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a reviewSemantic proximity Read ↗

Structural insights into the functional diversity of the CDK–cyclin familySemantic proximity Read ↗

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and presentSemantic proximity Read ↗

Degradation strategy of cyclin D1 in cancer cells and the potential clinical applicationSemantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity Read ↗

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosisSemantic proximity Read ↗

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage RepairSemantic proximity Read ↗

CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsSemantic proximity Read ↗

Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.