Article
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.
Molecular cancer - 6 Jul 2017
Berg Kaja C G, Eide Peter W, Eilertsen Ina A, Johannessen Bjarne, Bruun Jarle, Danielsen Stine A, Bjørnslett Merete, Meza-Zepeda Leonardo A, Eknæs Mette, Lind Guro E, Myklebost Ola, Skotheim Rolf I, Sveen Anita, Lothe Ragnhild A
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model selection for biomedical studies. METHODS: We have performed DNA, RNA and protein profiling of 34 cell lines, including (i) targeted deep sequencing (n = 612 genes) to detect single nucleotide variants and insertions/deletions; (ii) high...
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