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Article

Systematic analysis of genes required for synapse structure and function.

Nature - 28 Jul 2005

Sieburth Derek, Ch'ng QueeLim, Dybbs Michael, Tavazoie Masoud, Kennedy Scott, Wang Duo, Dupuy Denis, Rual Jean-François, Hill David E, Vidal Marc, Ruvkun Gary, Kaplan Joshua M

Abstract excerpt

Chemical synapses are complex structures that mediate rapid intercellular signalling in the nervous system. Proteomic studies suggest that several hundred proteins will be found at synaptic specializations. Here we describe a systematic screen to identify genes required for the function or development of Caenorhabditis elegans neuromuscular junctions. A total of 185 genes were identified in an RNA interference...

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PMID: 16049479
DOI: 10.1038/nature03809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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