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Article

An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.

PLoS genetics - 1 Jan 2009

Wang Jiou, Farr George W, Hall David H, Li Fei, Furtak Krystyna, Dreier Lars, Horwich Arthur L

Abstract excerpt

The nature of toxic effects exerted on neurons by misfolded proteins, occurring in a number of neurodegenerative diseases, is poorly understood. One approach to this problem is to measure effects when such proteins are expressed in heterologous neurons. We report on effects of an ALS-associated, misfolding-prone mutant human SOD1, G85R, when expressed in the neurons of Caenorhabditis elegans. Stable mutant...

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Identifiers

PMID: 19165329
DOI: 10.1371/journal.pgen.1000350
PMCID: PMC2621352

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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