Article
Dissection and molecular analysis of alloreactive CD8+ T cell responses in allogeneic haematopoietic stem cell transplantation.
Cancer immunology, immunotherapy : CII - 1 Jun 2008
Wölfel Catherine, Lennerz Volker, Lindemann Eva, Hess Georg, Derigs Hans G, Huber Christoph, Herr Wolfgang, Wölfel Thomas
Abstract excerpt
We applied a cDNA expression screening procedure with cryopreserved non-clonal CD8+ T cell populations (Lennerz et al., Proc. Natl. Acad. Sci. USA 102:16013-8, 2005) to the identification of candidate antigens for graft-versus-host disease (GvHD) and graft-versus-leukaemia (GvL) effects in allogeneic haematopoietic stem cell transplantation (allo-HSCT). In a patient-donor model system with HLA class I...
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