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Article

Stability of Protein-Specific Hydration Shell on Crowding.

Journal of the American Chemical Society - 27 Apr 2016

Huang Kuo-Ying, Kingsley Carolyn N, Sheil Ryan, Cheng Chi-Yuan, Bierma Jan C, Roskamp Kyle W, Khago Domarin, Martin Rachel W, Han Songi

Abstract excerpt

We demonstrate that the effect of protein crowding is critically dependent on the stability of the protein's hydration shell, which can dramatically vary between different proteins. In the human eye lens, γS-crystallin (γS-WT) forms a densely packed transparent hydrogel with a high refractive index, making it an ideal system for studying the effects of protein crowding. A single point mutation generates the...

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Identifiers

PMID: 27052457
DOI: 10.1021/jacs.6b01989
PMCID: PMC7849722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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