2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.

doi:10.1074/jbc.M708929200

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Article

2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.

The Journal of biological chemistry - 25 Jan 2008

Klumpp Klaus, Kalayanov Genadiy, Ma Han, Le Pogam Sophie, Leveque Vincent, Jiang Wen-Rong, Inocencio Nicole, De Witte Anniek, Rajyaguru Sonal, Tai Ezra, Chanda Sushmita, Irwin Michael R, Sund Christian, Winqist Anna, Maltseva Tatiana, Eriksson Staffan, Usova Elena, Smith Mark, Alker Andre, Najera Isabel, Cammack Nick, Martin Joseph A, Johansson Nils Gunnar, Smith David B

Abstract excerpt

RNA polymerases effectively discriminate against deoxyribonucleotides and specifically recognize ribonucleotide substrates most likely through direct hydrogen bonding interaction with the 2'-alpha-hydroxy moieties of ribonucleosides. Therefore, ribonucleoside analogs as inhibitors of viral RNA polymerases have mostly been designed to retain hydrogen bonding potential at this site for optimal inhibitory potency....

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PMID: 18003608
DOI: 10.1074/jbc.M708929200

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