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Article

Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

Antimicrobial agents and chemotherapy - 1 Jun 2009

Shi Stephanie T, Herlihy Koleen J, Graham Joanne P, Nonomiya Jim, Rahavendran Sadayappan V, Skor Heather, Irvine Rebecca, Binford Susan, Tatlock John, Li Hui, Gonzalez Javier, Linton Angelica, Patick Amy K, Lewis Cristina

Abstract excerpt

PF-00868554 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, which exerts its inhibitory effect by binding to the thumb base domain of the protein. It is a potent and selective inhibitor, with a mean 50% inhibitory concentration of 0.019 microM against genotype 1 polyme...

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Identifiers

PMID: 19307358
DOI: 10.1128/AAC.01599-08
PMCID: PMC2687230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19307358-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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