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Article

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Journal of medicinal chemistry - 13 Jul 2017

Zhou Shaoman, Mahmoud Sawsan, Liu Peng, Zhou Longhu, Ehteshami Maryam, Bassit Leda, Tao Sijia, Domaoal Robert A, Sari Ozkan, Schutter Coralie De, Amiralaei Sheida, Khalil Ahmed, Ollinger Russell Olivia, McBrayer Tamara, Whitaker Tony, Abou-Taleb Nageh, Amblard Franck, Coats Steven J, Schinazi Raymond F

Abstract excerpt

Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the discovery of a β-d-2'-Cl,2'-F-uridine phosphoramidate nucleotide 16, as a nontoxic pan-genotypic anti-HCV agent. Phosphoramidate 16 in its 5'-triphosphate form specifically inhibited HCV NS5B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28595015
DOI: 10.1021/acs.jmedchem.7b00067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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