Article
Discovery and characterization of substituted diphenyl heterocyclic compounds as potent and selective inhibitors of hepatitis C virus replication.
Antimicrobial agents and chemotherapy - 1 Apr 2008
Huang Peiyong, Goff Dane A, Huang Qi, Martinez Anthony, Xu Xiang, Crowder Scott, Issakani Sarkiz D, Anderson Emily, Sheng Ning, Achacoso Philip, Yen Ann, Kinsella Todd, Darwish Ihab S, Kolluri Rao, Hong Hui, Qu Kunbin, Stauffer Emily, Goldstein Eileen, Singh Rajinder, Payan Donald G, Lu H Henry
Abstract excerpt
A novel small-molecule inhibitor, referred to here as R706, was discovered in a high-throughput screen of chemical libraries against Huh-7-derived replicon cells carrying autonomously replicating subgenomic RNA of hepatitis C virus (HCV). R706 was highly potent in blocking HCV RNA replication as measured by real-time reverse transcription-PCR and Western blotting of R706-treated replicon cells. Structure-activity...
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