Article

Substrate and target selectivity of 4′-fluoroadenosine against viral and host polymerases

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Developing safe and effective treatments against emerging RNA viruses is an important goal in pandemic preparedness efforts. 4′-fluorouridine (4′-FlU) is a broad-spectrum antiviral that was shown to inhibit viral RNA-dependent RNA polymerases (RdRps). Given its notable range of antiviral activity, this class of nucleoside analogs warrants further investigation. Here, we studied the antiviral act...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 423aa090-0ccc-58be-b826-0e1b487e6b8c
DOI: 10.64898/2026.05.22.727251

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Substrate and target selectivity of 4′-fluoroadenosine against viral and host polymerasesDOI 10.64898/2026.05.22.727251Read

4’-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replicationSemantic proximity Read

Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation.Semantic proximity Read

Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA virusesSemantic proximity Read

Targeting viral genome synthesis as broad-spectrum approach against RNA virus infectionsSemantic proximity Read

Small Molecule Drugs Targeting Viral PolymerasesSemantic proximity Read

Inhibition of Viral RNA-Dependent RNA Polymerases by Nucleoside Inhibitors: An Illustration of the Unity and Diversity of MechanismsSemantic proximity Read

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivoSemantic proximity Read

An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challengesSemantic proximity Read

A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymeraseSemantic proximity Read

Oral 4’-fluorouridine completely suppresses epidemic Oropouche virus replication in mice and confers protection against virus-induced diseaseSemantic proximity Read

Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complexSemantic proximity Read

Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.Semantic proximity Read