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Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

Antimicrobial agents and chemotherapy - 1 Aug 2011

Berke Jan Martin, Vijgen Leen, Lachau-Durand Sophie, Powdrill Megan H, Rawe Svea, Sjuvarsson Elena, Eriksson Staffan, Götte Matthias, Fransen Els, Dehertogh Pascale, Van den Eynde Christel, Leclercq Laurent, Jonckers Tim H M, Raboisson Pierre, Nilsson Magnus, Samuelsson Bertil, Rosenquist Åsa, Fanning Gregory C, Lin Tse-I

Abstract excerpt

Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefore, there is a clear unmet medical need for efficacious and safe direct antiviral drugs for use in...

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Identifiers

PMID: 21576430
DOI: 10.1128/AAC.00214-11
PMCID: PMC3147651

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