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Article

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Journal of medicinal chemistry - 14 Oct 2010

Sofia Michael J, Bao Donghui, Chang Wonsuk, Du Jinfa, Nagarathnam Dhanapalan, Rachakonda Suguna, Reddy P Ganapati, Ross Bruce S, Wang Peiyuan, Zhang Hai-Ren, Bansal Shalini, Espiritu Christine, Keilman Meg, Lam Angela M, Steuer Holly M Micolochick, Niu Congrong, Otto Michael J, Furman Phillip A

Abstract excerpt

Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable target for the development of HCV therapies. β-d-2'-Deoxy-2'-α-fluoro-2'-β-C-methyl nucleosides are selective inhibitors of the HCV NS5B polymerase and have demonstrated potent activity in the clinic. Phosphoramidate prodrugs of the...

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PMID: 20845908
DOI: 10.1021/jm100863x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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