A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.

doi:10.1128/AAC.48.10.3944-3953.2004

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Article

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.

Antimicrobial agents and chemotherapy - 1 Oct 2004

Olsen David B, Eldrup Anne B, Bartholomew Linda, Bhat Balkrishen, Bosserman Michele R, Ceccacci Alessandra, Colwell Lawrence F, Fay John F, Flores Osvaldo A, Getty Krista L, Grobler Jay A, LaFemina Robert L, Markel Eric J, Migliaccio Giovanni, Prhavc Marija, Stahlhut Mark W, Tomassini Joanne E, MacCoss Malcolm, Hazuda Daria J, Carroll Steven S

Abstract excerpt

Improved treatments for chronic hepatitis C virus (HCV) infection are needed due to the suboptimal response rates and deleterious side effects associated with current treatment options. The triphosphates of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine were previously shown to be potent inhibitors of the HCV RNA-dependent RNA polymerase (RdRp) that is responsible for the replication of viral RNA in cells. Here...

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PMID: 15388457
DOI: 10.1128/AAC.48.10.3944-3953.2004
PMCID: PMC521892

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