PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

doi:10.1128/AAC.00399-10

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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Antimicrobial agents and chemotherapy - 1 Aug 2010

Lam Angela M, Murakami Eisuke, Espiritu Christine, Steuer Holly M Micolochick, Niu Congrong, Keilman Meg, Bao Haiying, Zennou Veronique, Bourne Nigel, Julander Justin G, Morrey John D, Smee Donald F, Frick David N, Heck Julie A, Wang Peiyuan, Nagarathnam Dhanapalan, Ross Bruce S, Sofia Michael J, Otto Michael J, Furman Phillip A

Abstract excerpt

The hepatitis C virus (HCV) NS5B RNA polymerase facilitates the RNA synthesis step during the HCV replication cycle. Nucleoside analogs targeting the NS5B provide an attractive approach to treating HCV infections because of their high barrier to resistance and pan-genotype activity. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine-5'-monophosphate, is a highly active nucleotide analog...

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PMID: 20516278
DOI: 10.1128/AAC.00399-10
PMCID: PMC2916354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.PMID 20516278Read ↗

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