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Article

Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.

Molecular pain - 14 Nov 2007

Plant Tim D, Zöllner Christian, Kepura Frauke, Mousa Shaaban S, Eichhorst Jenny, Schaefer Michael, Furkert Jens, Stein Christoph, Oksche Alexander

Abstract excerpt

BACKGROUND: Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes them to noxious stimuli, an effect probably mediated by the ETA receptor (ETAR) expressed in sensory neurons. The cellular mechanisms of this ET-1-mediated effect are only poorly understood. TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released in response to...

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Source

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Identifiers

PMID: 18001466
DOI: 10.1186/1744-8069-3-35
PMCID: PMC2206006

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.PMID 18001466Read ↗

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The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.Semantic proximity Read ↗

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