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Article

Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.

Neuron - 14 Aug 2008

Zhang Xuming, Li Lin, McNaughton Peter A

Abstract excerpt

The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes the release of inflammatory mediators which lower the threshold for detection of painful levels of heat, a proces...

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Source

Identifiers

PMID: 18701070
DOI: 10.1016/j.neuron.2008.05.015

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18701070-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.PMID 18701070Read ↗

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Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6Semantic proximity Read ↗

Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation.Semantic proximity Read ↗

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.Semantic proximity Read ↗

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