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Article

Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 May 2013

Btesh Joan, Fischer Michael J M, Stott Katherine, McNaughton Peter A

Abstract excerpt

Inflammation causes hyperalgesia, an enhanced sensitivity to noxious stimuli. Transient receptor potential vanilloid 1 (TRPV1), a thermo-TRP ion channel activated by painful levels of heat, is an important contributor because hyperalgesia is reduced when TRPV1 is either genetically deleted or pharmacologically blocked. Inflammatory mediators such as prostaglandin-E2 or bradykinin cause hyperalgesia by activating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23699529
DOI: 10.1523/JNEUROSCI.4991-12.2013
PMCID: PMC4212274

Genes

TRPV1
TAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.PMID 23699529Read ↗

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Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.Semantic proximity Read ↗

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