Article
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
The EMBO journal - 21 Dec 2005
Zhang Xuming, Huang Jiehong, McNaughton Peter A
Abstract excerpt
Nociceptors, or pain-sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion...
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