Article
Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.
Pain - 1 Apr 2011
Ristoiu Violeta, Shibasaki Koji, Uchida Kunitoshi, Zhou Yiming, Ton Bich-Hoai Thi, Flonta Maria-Luiza, Tominaga Makoto
Abstract excerpt
The capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), acts as a polymodal detector of pain-producing chemical and physical stimuli in sensory neurons. Hyperglycemia and hypoxia are two main phenomena in diabetes associated with several complications. Although many studies on streptozotocin-induced diabetic rats indicate that early diabetic neuropathy is associated with potentiation of TRPV1...
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