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Oxysterol, Oxy210, Inhibits Hepatic Expression of Senescence-Associated and Pro-Fibrotic Genes in Humanized Hyperlipidemic Mice During Development of MASH and in Human Hepatocytes In Vitro

2025-07-02

Abstract excerpt

<h4>Background: </h4> Senescence, a state of permanent cell cycle arrest, is a complex cellular phenomenon closely affiliated with age-related diseases and pathological fibrosis. Cellular senescence is now recognized as a significant contributor to organ fibrosis, largely driven by transforming growth factor beta (TGF-) signaling, such as in metabolic dysfunction-associated steatohepatitis (MASH), idiopathic pulm...

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Literature Corpus work: 6e9f581c-9161-58f7-a08f-4ce471f8951a
DOI: 10.20944/preprints202507.0149.v1

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Oxysterol, Oxy210, Inhibits Hepatic Expression of Senescence-Associated and Pro-Fibrotic Genes in Humanized Hyperlipidemic Mice During Development of MASH and in Human Hepatocytes In VitroDOI 10.20944/preprints202507.0149.v1Read

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